Acalabrutinib for leukemia and lymphoma is one tablet every 12 hours. Here is what 60 tablets — 30 days — cost in seven places.
Researched with AI assistance; every figure is checked against the primary source cited on this page before publishing. How we work →
Calquence 100 mg (acalabrutinib) is taken about every 12 hours for chronic lymphocytic leukemia, small lymphocytic lymphoma or mantle cell lymphoma (FDA label) — so 30 days = 60 tablets, which is also the European pack size. The two US list figures from CMS are for a “30-day supply” and are shown as published. US dollars at European Central Bank reference rates of November 6, 2026. The price types differ — list price, negotiated price, retail price — and are labelled.
CALQUENCE / ACALABRUTINIB 100 MG · 30 DAYS = 60 TABLETS
Price by country, November 2026
US list price: CMS figure for a 30-day supply (2024). No official price in Germany.
| Country | Official price | 30 days in US dollars | What a patient typically pays |
|---|---|---|---|
| 🇺🇸 United States (list, 2024) | $14,228 for a 30-day supply (CMS, 2024) | $14,228 | — |
| 🇺🇸 United States (Medicare, 2027) | $8,600 negotiated price per 30-day supply, from Jan 1, 2027 (CMS); $154.82328 per tablet | $9,289 | Depends on the Part D plan and coverage phase |
| 🇬🇧 United Kingdom | Calquence £5,059.00 for 60 tablets (NHS price, since Aug 9, 2023) | $6,771 | £9.90 per item in England; free in Scotland, Wales and Northern Ireland |
| 🇨🇭 Switzerland | Calquence CHF 4,745.45 for 60 tablets (public price; limitation) | $5,795 | 10% share after the annual deductible |
| 🇫🇷 France | Calquence €4,289.07 for 60 tablets (official price excluding dispensing fee) | $4,789 | Fully reimbursed (100%) |
| 🇦🇹 Austria | Calquence €5,365.15 for 60 tablets (social-insurance price excl. VAT; effective price may be lower under a price model) | $5,990 | €7.55 prescription fee per pack; insurer approval needed first |
| 🇳🇱 Netherlands | Calquence €4,930.69 for 60 tablets, €82.18 per tablet (average pharmacy price) | $5,505 | Fully reimbursed; counts toward the annual deductible |
| 🇩🇪 Germany | No statutory price ceiling (Festbetrag) for acalabrutinib; no official price found | — | — |
We compare prices; we do not recommend where to buy medicine. Cancer treatment decisions belong with your oncology team.
The $8,600 is the price Medicare negotiated under the Inflation Reduction Act, effective January 1, 2027. CMS bases it — like the $14,228 list price — on a 30-day supply calculated from 2024 prescription fills. Its data file sets $154.82328 per 100 mg tablet, so 60 tablets come to $9,289 (our calculation). In 2024 about 15,000 people with Medicare Part D used Calquence, and Part D spent $1.70 billion on it before rebates (CMS).
France, the Netherlands, Switzerland, Austria and the UK publish an official price for Calquence 100 mg — about $4,789 to $6,771 for 60 tablets at ECB rates, or 34% to 48% of the 2024 US list price (our calculation: $4,789 ÷ $14,228 and $6,771 ÷ $14,228). Medicare’s 2027 price per 60 tablets is about 1.9 times the French price (our calculation: $9,289 ÷ $4,789).
The NHS lists the 100 mg tablet since August 9, 2023 and marks the capsule pack discontinued from December 7, 2023 (dm+d); France lists the capsule as no longer marketed. The prices above are for tablets.
CMS recorded a US list price of $14,228 for a 30-day supply in 2024; Medicare’s negotiated price from January 1, 2027 is $8,600 (CMS). In Europe, 60 tablets of 100 mg cost €4,289.07 in France, €4,930.69 in the Netherlands, CHF 4,745.45 in Switzerland, €5,365.15 in Austria (excl. VAT) and £5,059.00 in the UK — about $4,789 to $6,771 at ECB rates.
CMS states the $8,600 for a 30-day supply calculated from 2024 prescription fills. Its data file prices each tablet at $154.82328; at two tablets a day, 60 tablets come to $9,289 (our calculation).
We found none: CMS negotiates only drugs without generic competition, and the UK, Swiss, Austrian and Dutch lists show only Calquence.
In England each prescription item costs £9.90; in France it is fully reimbursed; in Switzerland insured patients pay a 10% share after the deductible; in Austria a €7.55 prescription fee after the insurer approves it; in the Netherlands it is fully reimbursed but counts toward the annual deductible. In Medicare, it depends on the Part D plan.
The label dose is 100 mg about every 12 hours — 60 tablets for 30 days (FDA label).
Wellness Vision does not sell medicine, recommend pharmacies or suppliers, or take payments from drug makers. Every price above comes from the official source cited; currency conversions and 30-day figures are our own calculations, shown with their formula. This is a cost comparison, not medical advice.
You shouldn't have to go broke to feel whole.
